Back to Search Results

Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases.

Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile. Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, Porto, Portugal. Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal. Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, PRD, Portugal. Department of Scienze della Vita e dell'Ambiente, Drug Science Division, University of Cagliari, 09124 Cagliari, Italy. Department of Plant Physiology, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture, 94976 Nitra, Slovakia. Department of Plant Biology, Educational and Scientific Center "Institute of Biology and Medicine", Kiev National University of Taras Shevchenko, Volodymyrska, 64, 01033 Kyiv, Ukraine. Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, Ukraine. Department of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, Voli 1, Ternopil, Ukraine. Chemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386 Concepcion, Chile. Unidad de Desarrollo Tecnológico, Universidad de Concepción UDT, Concepcion 4070386, Chile. Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, 22272 Sharjah, UAE. Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Oxidative medicine and cellular longevity. 2021;:3149223
Full text from:

Other resources

Abstract

Due to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology applications used to enhance CUR bioavailability and its targeted delivery in specific pathological conditions are collected and discussed. In particular, new aspects concerning the main strategic nanocarriers employed for treating inflammation and oxidative stress-related diseases are reported and discussed, with specific emphasis on those topically employed in conditions such as wounds, arthritis, or psoriasis and others used in pathologies such as bowel (colitis), neurodegenerative (Alzheimer's or dementia), cardiovascular (atherosclerosis), and lung (asthma and chronic obstructive pulmonary disease) diseases. A brief overview of the relevant clinical trials is also included. We believe the review can provide the readers with an overview of the nanostrategies currently employed to improve CUR therapeutic applications in the highlighted pathological conditions.

Methodological quality

Publication Type : Review

Metadata

MeSH terms : Drug Carriers